I know that it says it can take 8-12 weeks before methotrexate takes affect. I am on my 4th week and so far no relief. I wish that I didn’t have a reaction to the Plaquenil cause I felt relief on it. And I am trying cbd capsules - that needs to be adjusted too cause I got no relief from that either. I am going to go back and look at the older post about methotrexate for what others have experienced.
It takes a while. The disease modifying meds need to be given a fair try of 6 months before giving up on them.